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Peptide record

TPDB37604

Neurotoxin Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB37604
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
RGCIELGEDCDGSKDDCQCCRDNGFCSCYTFPYKWGCIC
Physicochemical Analysis
C180H266N50O61S9
AHMV
C
4394.93
4.10
4
7
8
-3
6.36
-0.431
30.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8980
204.33
16
Residue Composition
number
0
A
2
R
1
N
5
D
9
C
2
E
1
Q
5
G
0
H
2
I
1
L
2
K
0
M
2
F
1
P
2
S
1
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 5 C: 9 E: 2 Q: 1 G: 5 H: 0 I: 2 L: 1 K: 2 M: 0 F: 2 P: 1 S: 2 T: 1 W: 1 Y: 2 V: 0
Chemical Descriptors
39
C180H266N50O61S9
4394.93
4.10
-3
6.36
-0.431
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav)..
U2-ctenitoxin-Co1a (U2-CNTX-Co1a) (Neurotoxin Oc F22)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
U2-ctenitoxin-Co1a (U2-CNTX-Co1a) (Neurotoxin Oc F22)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider