Back to search

Peptide record

TPDB37514

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB37514
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
RDCCTPPKKCKDRRCKPLKCCA
Physicochemical Analysis
C102H182N36O28S6
NEQGHIMFSWYV
C
2553.15
9.30
8
2
2
+6
9.16
-1.132
22.27
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
375
14.69
7
Residue Composition
number
1
A
3
R
0
N
2
D
6
C
0
E
0
Q
0
G
0
H
0
I
1
L
5
K
0
M
0
F
3
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 2 C: 6 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 5 M: 0 F: 0 P: 3 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C102H182N36O28S6
2553.15
9.30
+6
9.16
-1.132
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin shows potent activity on Nav1.4/SCN4A (IC(50)=286 nM), and weak activity on mNav1.6/SCN8A. {ECO:0000269|PubMed:30360356}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus geographus (Geography cone) (Nubecula geographus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin shows potent activity on Nav1.4/SCN4A (IC(50)=286 nM), and weak activity on mNav1.6/SCN8A..
Mu-conotoxin GIIIC
cone snail
Conotoxin M superfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:2410412}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin GIIIC
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:2410412}.
cone snail