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Peptide record

TPDB37479

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB37479
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
RCHFVVCTTDCRRNSPGTYGECVKKEKGKECVCKS
Physicochemical Analysis
C162H268N52O51S6
AQILMW
C
3952.59
8.58
9
4
6
+4
13.98
-0.769
33.14
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1865
47.18
13
Residue Composition
number
0
A
3
R
1
N
1
D
6
C
3
E
0
Q
3
G
1
H
0
I
0
L
5
K
0
M
1
F
1
P
2
S
3
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 6 E: 3 Q: 0 G: 3 H: 1 I: 0 L: 0 K: 5 M: 0 F: 1 P: 1 S: 2 T: 3 W: 0 Y: 1 V: 4
Chemical Descriptors
35
C162H268N52O51S6
3952.59
8.58
+4
13.98
-0.769
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv1.6/KCNA6 potassium channels. {ECO:0000269|PubMed:11361010}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Kv1.6/KCNA6 potassium channels..
Tamulustoxin (TmTX) (Potassium channel toxin alpha-KTx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11361010}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family
Tamulustoxin (TmTX) (Potassium channel toxin alpha-KTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11361010}.
scorpion