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Peptide record

TPDB37465

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB37465
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
RCCTGKKGSCSGRACKNLKCCA
Physicochemical Analysis
C86H157N33O27S6
DEQHIMFPWYV
C
2277.76
9.32
6
0
3
+6
4.09
-0.418
26.82
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
375
16.46
10
Residue Composition
number
2
A
2
R
1
N
0
D
6
C
0
E
0
Q
3
G
0
H
0
I
1
L
4
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 0 C: 6 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 4 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C86H157N33O27S6
2277.76
9.32
+6
4.09
-0.418
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin potently blocks rNav1.4/SCN4A (IC(50)= 7 nM). It also moderately blocks rNav1.1/SCN1A (IC(50)=370 nM), rNav1.2/SCN2A (IC(50)=1 uM), and mNav1.6/SCN6A (IC(50)=570 nM) (PubMed:18831583, PubMed:21652775). It is noteworthy that coexpression of subunits beta-2 or beta-4 (but not beta-1 or beta-3) decrease by more that 10-fold the binding potency of the toxin to rNav1.6 (PubMed:25632083). It is also noteworthy that the toxin is 50-fold more potent on mouse Nav1.6 than on rat Nav1.6 (PubMed:25632083). In vivo, when injected intraperitoneally or subcutaneously in mice, causes motor impairment, paralysis and death (PubMed:18831583). {ECO:0000269|PubMed:18831583, ECO:0000269|PubMed:21652775}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus striolatus (Cone snail)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin potently blocks rNav1.4/SCN4A (IC(50)= 7 nM).
Mu-conotoxin SxIIIA
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18831583}.
Additional Detail Fields 7 fields
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin SxIIIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18831583}.
cone snail