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Peptide record

TPDB37427

Neurotoxin Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB37427
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 44-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
RACIELGEDCDGYKDDCQCCRDNAFCSCYEFFGEKNGCGCAVGH
Physicochemical Analysis
C196H289N57O69S9
MPTW
C
4836.33
4.13
5
9
11
-5
11.66
-0.432
31.14
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
3480
71.96
15
Residue Composition
number
3
A
2
R
2
N
5
D
9
C
4
E
1
Q
6
G
1
H
1
I
1
L
2
K
0
M
3
F
0
P
1
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 5 C: 9 E: 4 Q: 1 G: 6 H: 1 I: 1 L: 1 K: 2 M: 0 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
44
C196H289N57O69S9
4836.33
4.13
-5
11.66
-0.432
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-sensitive calcium channels (Cav) (By similarity). Toxic to mice by intracerebroventricular injection. {ECO:0000250, ECO:0000269|Ref.1}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-sensitive calcium channels (Cav) (By similarity). Toxic to mice by intracerebroventricular injection..
U17-ctenitoxin-Co1a (U17-CNTX-Co1a) (Neurotoxin Oct F27-10)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
U17-ctenitoxin-Co1a (U17-CNTX-Co1a) (Neurotoxin Oct F27-10)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider