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Peptide record

TPDB37342

Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB37342
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
QTCCGYRMCVPC
Physicochemical Analysis
C53H86N16O16S5
ANDEHILKFSW
C
1363.66
7.84
1
0
3
+1
-0.07
0.342
24.17
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
1740
127.60
7
Residue Composition
number
0
A
1
R
0
N
0
D
4
C
0
E
1
Q
1
G
0
H
0
I
0
L
0
K
1
M
0
F
1
P
0
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C53H86N16O16S5
1363.66
7.84
+1
-0.07
0.342
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2). {ECO:0000250|UniProtKB:P58808}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus textile (Cloth-of-gold cone)
Neurotoxin
Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2)..
Chi-conotoxin-like 2 (Tx10c)
cone snail
Conotoxin T superfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Oxidation Pyrrolidone carboxylic acid Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:19380747, ECO:0000305|PubMed:22709442}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Oxidation Pyrrolidone carboxylic acid Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin T superfamily
Chi-conotoxin-like 2 (Tx10c)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:19380747, ECO:0000305|PubMed:22709442}.
cone snail