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Peptide record

TPDB37299

Neurotoxin Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB37299
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
QSPGCCWNPACVKNRC
Physicochemical Analysis
C71H112N24O21S4
DEHILMFTY
C
1766.06
8.31
2
0
3
+2
1.35
-0.513
24.38
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5750
325.58
8
Residue Composition
number
1
A
1
R
2
N
0
D
4
C
0
E
1
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
2
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 0 C: 4 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
16
C71H112N24O21S4
1766.06
8.31
+2
1.35
-0.513
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin causes paralysis upon intramuscular injection into goldfish and blocks both fetal (alpha-1/beta-1/delta-gamma subunits) and adult (alpha-1/beta-1/delta-epsilon subunits) subtypes of vertebrate muscle nAChRs in a dose-dependent manner. {ECO:0000269|PubMed:17382984}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus purpurascens (Purple cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin causes paralysis upon intramuscular injection into goldfish and blocks both fetal (alpha-1/beta-1/delta-gamma subunits) and adult (alpha-1/beta-1/delta-epsilon subunits) subtypes of vertebrate muscle nAChRs in a dose-dependent manner..
Alpha-conotoxin PIB
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17382984}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin PIB
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17382984}.
cone snail