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Peptide record

TPDB36938

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB36938
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
QNETNKKCQGGSCASVCRRVIGVAAGKCINGRCVCYP
Physicochemical Analysis
C156H266N54O49S6
DHLMFW
C
3874.52
8.90
6
1
10
+5
7.51
-0.195
60.54
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
1865
48.13
15
Residue Composition
number
3
A
3
R
3
N
0
D
6
C
1
E
2
Q
5
G
0
H
2
I
0
L
3
K
0
M
0
F
1
P
2
S
1
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 3 R: 3 N: 3 D: 0 C: 6 E: 1 Q: 2 G: 5 H: 0 I: 2 L: 0 K: 3 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 1 V: 4
Chemical Descriptors
37
C156H266N54O49S6
3874.52
8.90
+5
7.51
-0.195
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocker of voltage-gated potassium channels (600 nM of the toxin induces a block of 25% of hERG currents) (PubMed:18687312). May also inhibit Kv4/KCND when coexpressed with DPP6 or DPP10 (By similarity). In adult rat brain, it blocks the transient potassium channels in cerebellum granular cells. Blocks potassium channels by a simple 'plugging mechanism', in which a single toxin molecule finds a specific receptor site in the external vestibule of the potassium channel and thereby occludes the outer entry to the potassium conducting pore (PubMed:11018665). {ECO:0000250|UniProtKB:P60208, ECO:0000269|PubMed:11018665, ECO:0000269|PubMed:18687312}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Androctonus australis (Sahara scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocker of voltage-gated potassium channels (600 nM of the toxin induces a block of 25% of hERG currents) (PubMed:18687312). May also inhibit Kv4/KCND when coexpressed with DPP6 or DPP10 (By similarity).
Potassium channel toxin alpha-KTx 15.1 (Peptide Aa1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 15 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 15 subfamily
Potassium channel toxin alpha-KTx 15.1 (Peptide Aa1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion