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Peptide record

TPDB36929

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB36929
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
QNCCNGGCSSKWCKGHARCC
Physicochemical Analysis
C81H129N31O26S6
DEILMFPTYV
C
2145.47
8.32
4
0
2
+3
2.00
-0.645
5.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5875
273.83
11
Residue Composition
number
1
A
1
R
2
N
0
D
6
C
0
E
1
Q
3
G
1
H
0
I
0
L
2
K
0
M
0
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 0 C: 6 E: 0 Q: 1 G: 3 H: 1 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
20
C81H129N31O26S6
2145.47
8.32
+3
2.00
-0.645
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (VGSC). Potently displaces (125)I-TIIIA from native rat brain Nav1.2/SCN2A (IC(50) is 5 nM) and muscle Nav1.4/SCN4A (IC(50) is 3 nM) VGSCs. Potently and irreversibly inhibits current through Xenopus oocyte-expressed Nav1.2/SCN2A and Nav1.4/SCN4A. {ECO:0000269|PubMed:18522941}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus striatus (Striated cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (VGSC). Potently displaces (125)I-TIIIA from native rat brain Nav1.2/SCN2A (IC(50) is 5 nM) and muscle Nav1.4/SCN4A (IC(50) is 3 nM) VGSCs.
Mu-conotoxin SIIIB
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18522941}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin SIIIB
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18522941}.
cone snail