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Peptide record

TPDB36869

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB36869
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
QKCCTGKKGSCSGRACKNLRCCA
Physicochemical Analysis
C91H165N35O29S6
DEHIMFPWYV
C
2405.89
9.32
6
0
3
+6
4.67
-0.552
25.65
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
375
15.59
11
Residue Composition
number
2
A
2
R
1
N
0
D
6
C
0
E
1
Q
3
G
0
H
0
I
1
L
4
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 0 C: 6 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 1 K: 4 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
23
C91H165N35O29S6
2405.89
9.32
+6
4.67
-0.552
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus striolatus (Cone snail)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav)..
Mu-conotoxin-like SxIIIB
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18831583}.
Additional Detail Fields 7 fields
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin-like SxIIIB
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18831583}.
cone snail