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Peptide record

TPDB36868

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB36868
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
QKCCSGGSCPLYFRDRLICPCC
Physicochemical Analysis
C101H162N30O29S6
ANEHMTWV
C
2452.94
8.02
3
1
5
+2
0.66
0.141
53.18
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
1865
76.03
10
Residue Composition
number
0
A
2
R
0
N
1
D
6
C
0
E
1
Q
2
G
0
H
1
I
2
L
1
K
0
M
1
F
2
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 6 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 2 K: 1 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C101H162N30O29S6
2452.94
8.02
+2
0.66
0.141
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable competitive antagonist of fish muscle acetylcholine receptor. Inhibits postsynaptic nicotinic acetylcholine receptors (nAChRs) from fish (zebrafish and goldfish) and frogs (IC(50)=0.1 uM). Protects these receptors from block by alpha-bungarotoxin and alpha-conotoxin EI. Does not block nAChRs at the neuromuscular junction of Rana pipiens. Shows a weak inhibition on mammalian adult and fetal muscle nAChRs (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE and alpha-1 beta-1 gamma delta/CHRNA1-CHRNB1-CHRNG-CHRND) (IC(50)=3-45 uM). In vivo, induces paralysis in goldfish (Carassius auratus) but not mice. {ECO:0000269|PubMed:32245200}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus magus (Magical cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Probable competitive antagonist of fish muscle acetylcholine receptor. Inhibits postsynaptic nicotinic acetylcholine receptors (nAChRs) from fish (zebrafish and goldfish) and frogs (IC(50)=0.1 uM).
Conotoxin MIIIJ (AlphaM-MIIIJ)
cone snail
Conotoxin M superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:32245200}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin M superfamily
Conotoxin MIIIJ (AlphaM-MIIIJ)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:32245200}.
cone snail