Back to search

Peptide record

TPDB36776

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB36776
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
QKECTGPQHCTNFCRKNKCTHGKCMNRKCKCFNCK
Physicochemical Analysis
C165H272N58O47S9
ADILSWYV
C
4108.88
9.32
11
1
3
+8
11.81
-1.263
0.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
500
12.17
17
Residue Composition
number
0
A
2
R
4
N
0
D
8
C
1
E
2
Q
2
G
2
H
0
I
0
L
7
K
1
M
2
F
1
P
0
S
3
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 4 D: 0 C: 8 E: 1 Q: 2 G: 2 H: 2 I: 0 L: 0 K: 7 M: 1 F: 2 P: 1 S: 0 T: 3 W: 0 Y: 0 V: 0
Chemical Descriptors
35
C165H272N58O47S9
4108.88
9.32
+8
11.81
-1.263
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: High affinity blocker of Kv1.3/KCNA3 channels of human T cells. Blocks Kv1.2/KCNA2 with an order of magnitude smaller than for Kv1.3/KCNA3. {ECO:0000269|PubMed:15615696}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anuroctonus phaiodactylus (Mafia scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
High affinity blocker of Kv1.3/KCNA3 channels of human T cells. Blocks Kv1.2/KCNA2 with an order of magnitude smaller than for Kv1.3/KCNA3..
Potassium channel toxin alpha-KTx 6.12 (Anuroctoxin)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.12 (Anuroctoxin)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion