Back to search

Peptide record

TPDB36766

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB36766
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
QIETNKKCQGGSCASVCRKVIGVAAGKCINGRCVCYP
Physicochemical Analysis
C158H271N51O48S6
DHLMFW
C
3845.56
8.89
6
1
11
+5
6.96
0.038
71.08
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
1865
48.50
14
Residue Composition
number
3
A
2
R
2
N
0
D
6
C
1
E
2
Q
5
G
0
H
3
I
0
L
4
K
0
M
0
F
1
P
2
S
1
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 0 C: 6 E: 1 Q: 2 G: 5 H: 0 I: 3 L: 0 K: 4 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 1 V: 4
Chemical Descriptors
37
C158H271N51O48S6
3845.56
8.89
+5
6.96
0.038
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits A-type (Kv4) voltage-gated potassium channels of striated neurons (Ki=131 nM), probably by acting as a pore blocker (PubMed:12473099, PubMed:23440961, PubMed:30529150). Has also been shown to block ERG1/Kv11.1/KCNH2 potassium channels (IC(50)=7.9 uM) (PubMed:18687312). The presence of the Kv4-associated proteins DPP6 or DPP10 is mandatory to have high-affinity blockade of Kv4.2/KCND2 and Kv4.3/KCND3 channels (80-90% inhibition at 500 nM of toxin) (PubMed:23440961). In contrast, the presence of the Kv4-associated protein KChIP1/KCNIP1 does not enhance the affinity blockade (only 40% inhibition at 500 nM) (PubMed:23440961). In adult rat brain, the toxin binds to sites in the striatum, and cerebellum. It shares the same target in rat brain than AaTX1 (AC Q867F4) and BmTX3 (AC Q8I0L5). In DPP6 knockout mice, A-type currents are about 20-fold less affected by the toxin (PubMed:23440961). In rodent models of Parkinson's disease, the toxin reduces motor symptoms and emotional and cognitive symptoms (PubMed:25356731). {ECO:0000269|PubMed:12473099, ECO:0000269|PubMed:18687312, ECO:0000269|PubMed:23440961, ECO:0000269|PubMed:25356731, ECO:0000269|PubMed:30529150}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Androctonus mauritanicus mauritanicus (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits A-type (Kv4) voltage-gated potassium channels of striated neurons (Ki=131 nM), probably by acting as a pore blocker (PubMed:12473099, PubMed:23440961, PubMed:30529150). Has also been shown to block ERG1/Kv11.1/KCNH2 potassium channels (IC(50)=7.9 uM) (PubMed:18687312).
Potassium channel toxin alpha-KTx 15.3 (Toxin AmmTX3)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 15 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 15 subfamily
Potassium channel toxin alpha-KTx 15.3 (Toxin AmmTX3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion