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Peptide record

TPDB36705

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB36705
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
QGCCNVPNGCSGRWCRDHAQCC
Physicochemical Analysis
C91H141N35O30S6
EILKMFTY
C
2397.70
7.64
3
1
3
+1
3.03
-0.600
17.73
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5875
245.03
11
Residue Composition
number
1
A
2
R
2
N
1
D
6
C
0
E
2
Q
3
G
1
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 1 C: 6 E: 0 Q: 2 G: 3 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C91H141N35O30S6
2397.70
7.64
+1
3.03
-0.600
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin potently blocks rNav1.3/SCN3A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, rNav1.4/SCN4A, mNav1.6/SCN8A, and Nav1.7/SCN9A. sodium channels. This block is very slowly reversible. {ECO:0000269|PubMed:21652775}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus magus (Magical cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin potently blocks rNav1.3/SCN3A.
Mu-conotoxin MIIIA
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:16533055}.
Additional Detail Fields 7 fields
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin MIIIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:16533055}.
cone snail