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Peptide record

TPDB36703

Neurotoxin Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB36703
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
QGCCGEPNLCFTRWCRNNARCCRQQ
Physicochemical Analysis
C116H184N44O35S6
DHIKMSYV
C
2947.37
8.32
4
1
4
+3
3.72
-0.924
19.60
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5875
199.33
13
Residue Composition
number
1
A
4
R
3
N
0
D
6
C
1
E
3
Q
2
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 3 D: 0 C: 6 E: 1 Q: 3 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C116H184N44O35S6
2947.37
8.32
+3
3.72
-0.924
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks slightly but irreversibly tetrodotoxin-resistant VGSCs.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus consors (Singed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks slightly but irreversibly tetrodotoxin-resistant VGSCs.
Mu-conotoxin CnIIIB
cone snail
Conotoxin M superfamily
Evidence at protein level
Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin CnIIIB
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail