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Peptide record

TPDB36702

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB36702
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
QFTNVSCTTSKECWSVCEKLYNTSRGKCMNKKCRCYS
Physicochemical Analysis
C179H287N53O57S7
ADHIP
C
4317.99
8.86
7
2
8
+5
6.72
-0.765
26.22
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
8855
205.07
21
Residue Composition
number
0
A
2
R
3
N
0
D
6
C
2
E
1
Q
1
G
0
H
0
I
1
L
5
K
1
M
1
F
0
P
5
S
4
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 3 D: 0 C: 6 E: 2 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 5 M: 1 F: 1 P: 0 S: 5 T: 4 W: 1 Y: 2 V: 2
Chemical Descriptors
37
C179H287N53O57S7
4317.99
8.86
+5
6.72
-0.765
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent selective inhibitor of high conductance (maxi-K), different medium and small conductance calcium-activated potassium channels (KCa1.1/KCNMA1 and others), as well as a voltage-dependent potassium channel (Kv1.3/KCNA3>Kv1.2/KCNA2>Kv1.6/KCNA3>>Shaker/Sh). It blocks channel activity by a simple bimolecular inhibition process. {ECO:0000250|UniProtKB:P13487}. FUNCTION: Has a pH-specific antimicrobial activity against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans. {ECO:0000250|UniProtKB:P13487}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Leiurus hebraeus (Hebrew deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent selective inhibitor of high conductance (maxi-K), different medium and small conductance calcium-activated potassium channels (KCa1.1/KCNMA1 and others), as well as a voltage-dependent potassium channel (Kv1.3/KCNA3>Kv1.2/KCNA2>Kv1.6/KCNA3>>Shaker/Sh). It blocks channel activity by a simple bimolecular inhibition process.. FUNCTION: Has a pH-specific antimicrobial activity against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans..
Potassium channel toxin alpha-KTx 1.13 (Charybdotoxin c) (ChTx-c)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Evidence at protein level
Antibiotic Antimicrobial Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Fungicide Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Antibiotic Antimicrobial Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Fungicide Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Potassium channel toxin alpha-KTx 1.13 (Charybdotoxin c) (ChTx-c)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion