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Peptide record

TPDB36650

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB36650
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
QFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
Physicochemical Analysis
C179H283N51O55S7
ANHIP
C
4253.95
8.01
7
5
10
+2
8.23
-0.443
41.89
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
7365
173.13
13
Residue Composition
number
0
A
2
R
0
N
4
D
6
C
1
E
2
Q
3
G
0
H
0
I
1
L
5
K
1
M
2
F
0
P
3
S
1
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 4 C: 6 E: 1 Q: 2 G: 3 H: 0 I: 0 L: 1 K: 5 M: 1 F: 2 P: 0 S: 3 T: 1 W: 1 Y: 1 V: 4
Chemical Descriptors
37
C179H283N51O55S7
4253.95
8.01
+2
8.23
-0.443
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks selectively the high conductance calcium-activated (maxi-K) potassium channels (KCa1.1/KCNMA1).

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks selectively the high conductance calcium-activated (maxi-K) potassium channels (KCa1.1/KCNMA1).
Potassium channel toxin alpha-KTx 1.3 (Iberiotoxin) (IbTx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Pyrrolidone carboxylic acid Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Potassium channel toxin alpha-KTx 1.3 (Iberiotoxin) (IbTx)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion