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Peptide record

TPDB36482

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB36482
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
QAIGLPHTACIQCNRKTSSKCLSGQICLPYHMTCYTLYKPDENGELK
Physicochemical Analysis
C226H363N63O69S6
FWV
CL
5259.11
8.13
7
3
14
+2
8.55
-0.406
70.64
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
4720
89.75
20
Residue Composition
number
2
A
1
R
2
N
1
D
5
C
2
E
3
Q
3
G
2
H
3
I
5
L
4
K
1
M
0
F
3
P
3
S
4
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 1 C: 5 E: 2 Q: 3 G: 3 H: 2 I: 3 L: 5 K: 4 M: 1 F: 0 P: 3 S: 3 T: 4 W: 0 Y: 3 V: 0
Chemical Descriptors
47
C226H363N63O69S6
5259.11
8.13
+2
8.55
-0.406
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This toxin may inhibit nicotinic acetylcholine receptor (nAChR). It has poorly reversible postsynaptic blocking activity in a chick muscle preparation and readily reversible inhibitory activity at a presynaptic site in the rat vas deferens prostatic segment most likely to prevent the release of neurotransmitters. {ECO:0000269|PubMed:15683871}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Boiga dendrophila (Mangrove snake) (Gold-ringed cat snake)
Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
This toxin may inhibit nicotinic acetylcholine receptor (nAChR). It has poorly reversible postsynaptic blocking activity in a chick muscle preparation and readily reversible inhibitory activity at a presynaptic site in the rat vas deferens prostatic segment most likely to prevent the release of neurotransmitters..
Boigatoxin-A
snake
Three-finger toxin family, Ancestral subfamily, Boigatoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12955733}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Ancestral subfamily, Boigatoxin sub-subfamily
Boigatoxin-A
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12955733}.
snake