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Peptide record

TPDB36232

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB36232
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
PLFDKRQRCCNGRRGCSSRWCRDHSRCCGRR
Physicochemical Analysis
C147H244N64O41S6
AEIMTYV
R
3756.32
10.97
11
2
3
+8
8.59
-1.487
12.58
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5875
156.40
11
Residue Composition
number
0
A
9
R
1
N
2
D
6
C
0
E
1
Q
3
G
1
H
0
I
1
L
1
K
0
M
1
F
1
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 1 D: 2 C: 6 E: 0 Q: 1 G: 3 H: 1 I: 0 L: 1 K: 1 M: 0 F: 1 P: 1 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
31
C147H244N64O41S6
3756.32
10.97
+8
8.59
-1.487
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin blocks rNav1.5/SCN5A (IC(50) is 1.3 uM), rNav1.6/SCN8A (IC(50) is 160 nM), rNav1.7/SCN9A (IC(50) is 1.3 uM), rNav1.1/SCN1A (K(d) is 3.8 nM), rNav1.2/SCN2A (K(d) is 1.3 nM), rNav1.4/SCN4A (K(d) is 0.22 nM), rNav1.6/SCN8A (K(d) is 69 nM), and rNav1.7/SCN9A (K(d) is 260 nM). This toxin is very potent but weakly discriminating among sodium channels. The block of these channels is modified when beta-subunits are coexpressed with alpha subunits. Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 subunits are less potent (compared to channels without beta subunits). {ECO:0000269|PubMed:12484778, ECO:0000269|PubMed:21652775, ECO:0000269|PubMed:22229737, ECO:0000269|PubMed:23146020}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus stercusmuscarum (Fly-specked cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin blocks rNav1.5/SCN5A (IC(50) is 1.3 uM), rNav1.6/SCN8A (IC(50) is 160 nM), rNav1.7/SCN9A (IC(50) is 1.3 uM), rNav1.1/SCN1A (K(d) is 3.8 nM), rNav1.2/SCN2A (K(d) is 1.3 nM), rNav1.4/SCN4A (K(d) is 0.22 nM), rNav1.6/SCN8A (K(d) is 69 nM), and rNav1.7/SCN9A (K(d) is 260 nM).
Mu-conotoxin SmIIIA
cone snail
Conotoxin M superfamily
Evidence at transcript level
3D-structure Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
3D-structure Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin M superfamily
Mu-conotoxin SmIIIA
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail