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Peptide record

TPDB36043

Antifungal Toxicity standard
145 amino acids
Basic Information
3D PDB MODEL
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TPDB36043
Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 145-aa standard natural multi-activity (Antifungal and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
PAGPFRIPKCRKEFQQAQHLRACQQWLHKQAMQSGSGPSWTLDDEFDFEDDMENPQGPQQRPPLLQQCCNELHQEEPLCVCPTLKGASKAVKQQVRQQLGQQGQQGPHLQHVISRIYQTATHLPKVCNIRQVSVCPFKKTMPGPS
Physicochemical Analysis
C714H1126N216O210S11
Q
16448.78
8.31
22
12
40
+4
43.26
-0.832
59.17
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
12990
78.97
48
Residue Composition
number
7
A
7
R
3
N
5
D
8
C
7
E
24
Q
9
G
6
H
4
I
11
L
9
K
3
M
5
F
15
P
7
S
5
T
2
W
1
Y
7
V
Amino Acid Distribution
A: 7 R: 7 N: 3 D: 5 C: 8 E: 7 Q: 24 G: 9 H: 6 I: 4 L: 11 K: 9 M: 3 F: 5 P: 15 S: 7 T: 5 W: 2 Y: 1 V: 7
Chemical Descriptors
145
C714H1126N216O210S11
16448.78
8.31
+4
43.26
-0.832
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antifungal
13-16 µM

Target

K. lactis ATCC 56498

Source & Reference

NA

Other

Active against fungi and yeasts K. lactis ATCC 56498 (MIC 13-16 uM), D. hansenii CBS 2334 (MIC 9-13 uM), Z. bailii Sa 1403 (MIC 3-6 uM), Z. rouxii ATCC 14679
Evidence 2 Activity

Activity

MIC
Antifungal
9-13 µM

Target

D. hansenii CBS 2334

Source & Reference

NA

Other

Active against fungi and yeasts K. lactis ATCC 56498 (MIC 13-16 uM), D. hansenii CBS 2334 (MIC 9-13 uM), Z. bailii Sa 1403 (MIC 3-6 uM), Z. rouxii ATCC 14679 (MIC 25-31 uM), S. cerevisiae DSM 7
Evidence 3 Activity

Activity

MIC
Antifungal
3-6 µM

Target

Z. bailii Sa 1403

Source & Reference

NA

Other

fungi and yeasts K. lactis ATCC 56498 (MIC 13-16 uM), D. hansenii CBS 2334 (MIC 9-13 uM), Z. bailii Sa 1403 (MIC 3-6 uM), Z. rouxii ATCC 14679 (MIC 25-31 uM), S. cerevisiae DSM 70449, or strain NCYC 77 (MIC 6-1
Evidence 4 Activity

Activity

MIC
Antifungal
25-31 µM

Target

Z. rouxii ATCC 14679

Source & Reference

NA

Other

56498 (MIC 13-16 uM), D. hansenii CBS 2334 (MIC 9-13 uM), Z. bailii Sa 1403 (MIC 3-6 uM), Z. rouxii ATCC 14679 (MIC 25-31 uM), S. cerevisiae DSM 70449, or strain NCYC 77 (MIC 6-13 uM), strain MTU 01P (MIC 63 uM), C.
Evidence 5 Activity

Activity

MIC
Antifungal
63 µM

Target

Candida albicans CUH 001

Source & Reference

NA

Other

M), S. cerevisiae DSM 70449, or strain NCYC 77 (MIC 6-13 uM), strain MTU 01P (MIC 63 uM), C. albicans CUH 001 (MIC 63 uM), F. culmorum FST 4.05 (MIC 3-6 uM), A. fumigatus DSM 15966 (MIC 63 uM). Not active agains
Evidence 6 Activity

Activity

MIC
Antifungal
63 µM

Target

A. fumigatus DSM 15966

Source & Reference

NA

Other

MTU 01P (MIC 63 uM), C. albicans CUH 001 (MIC 63 uM), F. culmorum FST 4.05 (MIC 3-6 uM), A. fumigatus DSM 15966 (MIC 63 uM). Not active against E.coli ATCC 25922 and M.luteus CIT3.