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Peptide record

TPDB36022

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB36022
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NVDFNSESTRRKKKQKEIVDLHNSLRRRVSPTA
Physicochemical Analysis
C165H282N58O52
CGMWY
R
3910.41
11.41
10
4
8
+5
16.04
-1.400
64.85
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
10
Residue Composition
number
1
A
5
R
3
N
2
D
0
C
2
E
1
Q
0
G
1
H
1
I
2
L
4
K
0
M
1
F
1
P
4
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 5 N: 3 D: 2 C: 0 E: 2 Q: 1 G: 0 H: 1 I: 1 L: 2 K: 4 M: 0 F: 1 P: 1 S: 4 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
33
C165H282N58O52
3910.41
11.41
+5
16.04
-1.400
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (Cav) (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Naja naja (Indian cobra)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (Cav) (By similarity)..
Cysteine-rich venom protein (CRVP) (Cysteine-rich secretory protein 1) (CRISP1) (Cysteine-rich secretory protein 2) (CRISP2) (Najanajin)
snake
CRISP family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Reference proteome Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:20203422}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Reference proteome Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
CRISP family
Cysteine-rich venom protein (CRVP) (Cysteine-rich secretory protein 1) (CRISP1) (Cysteine-rich secretory protein 2) (CRISP2) (Najanajin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:20203422}.
snake