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Peptide record

TPDB36017

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB36017
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
NWSWCSGSGEGCDYHSECCGERCCIESMCIGDGVACWP
Physicochemical Analysis
C167H239N47O58S9
QLKFT
C
4121.55
3.82
2
6
9
-5
4.53
-0.192
30.79
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
18490
448.62
15
Residue Composition
number
1
A
1
R
1
N
2
D
8
C
4
E
0
Q
6
G
1
H
2
I
0
L
0
K
1
M
0
F
1
P
5
S
0
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 2 C: 8 E: 4 Q: 0 G: 6 H: 1 I: 2 L: 0 K: 0 M: 1 F: 0 P: 1 S: 5 T: 0 W: 3 Y: 1 V: 1
Chemical Descriptors
38
C167H239N47O58S9
4121.55
3.82
-5
4.53
-0.192
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus lynceus (Lynceus cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like L11.5
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like L11.5
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail