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Peptide record

TPDB35966

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB35966
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NPASCCSCADVDPGRASRKTPKGEDQVFIKEKDRC
Physicochemical Analysis
C155H256N50O54S4
HLMWY
DCK
3812.28
7.84
7
6
7
+1
15.48
-0.991
36.29
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
250
6.56
10
Residue Composition
number
3
A
3
R
1
N
4
D
4
C
2
E
1
Q
2
G
0
H
1
I
0
L
4
K
0
M
1
F
3
P
3
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 3 N: 1 D: 4 C: 4 E: 2 Q: 1 G: 2 H: 0 I: 1 L: 0 K: 4 M: 0 F: 1 P: 3 S: 3 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
35
C155H256N50O54S4
3812.28
7.84
+1
15.48
-0.991
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus textile (Cloth-of-gold cone)
Neurotoxin
Conotoxin TxMEKL-0422
cone snail
Evidence at transcript level
Cleavage on pair of basic residues Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 6 fields
Cleavage on pair of basic residues Disulfide bond Neurotoxin Secreted Toxin
Neurotoxin
Evidence at transcript level
Conotoxin TxMEKL-0422
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail