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Peptide record

TPDB35961

Neurotoxin Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB35961
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NLYQFKNMIQCTTKRSVLEFMEYGCYC
Physicochemical Analysis
C146H222N36O42S5
ADHPW
CY
3313.88
8.00
3
2
11
+1
1.63
-0.244
54.07
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
4595
138.66
13
Residue Composition
number
0
A
1
R
2
N
0
D
3
C
2
E
2
Q
1
G
0
H
1
I
2
L
2
K
2
M
2
F
0
P
1
S
2
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 3 E: 2 Q: 2 G: 1 H: 0 I: 1 L: 2 K: 2 M: 2 F: 2 P: 0 S: 1 T: 2 W: 0 Y: 3 V: 1
Chemical Descriptors
27
C146H222N36O42S5
3313.88
8.00
+1
1.63
-0.244
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Micrurus nigrocinctus (Central American coral snake) (Gargantilla)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group I subfamily
Evidence at protein level
Calcium Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group I subfamily
Phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake