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Peptide record

TPDB35938

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB35938
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NLYQFKNMIECAGTRTWIAYVKYGAYTYAYT
Physicochemical Analysis
C173H248N40O47S2
DHPS
Y
3704.23
9.23
3
1
17
+2
-4.07
-0.232
60.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
14440
389.82
14
Residue Composition
number
4
A
1
R
2
N
0
D
1
C
1
E
1
Q
2
G
0
H
2
I
1
L
2
K
1
M
1
F
0
P
0
S
4
T
1
W
6
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 2 D: 0 C: 1 E: 1 Q: 1 G: 2 H: 0 I: 2 L: 1 K: 2 M: 1 F: 1 P: 0 S: 0 T: 4 W: 1 Y: 6 V: 1
Chemical Descriptors
31
C173H248N40O47S2
3704.23
9.23
+2
-4.07
-0.232
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity). {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity)..
Basic phospholipase A2 13 (svPLA2) (EC 3.1.1.4) (Cytotoxin XIII) (Phosphatidylcholine 2-acylhydrolase) (Phospholipase A2 XIII)
snake
Phospholipase A2 family, Group I subfamily
Evidence at protein level
Calcium Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group I subfamily
Basic phospholipase A2 13 (svPLA2) (EC 3.1.1.4) (Cytotoxin XIII) (Phosphatidylcholine 2-acylhydrolase) (Phospholipase A2 XIII)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake