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Peptide record

TPDB35937

Neurotoxin Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB35937
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NLYQFKEMIRYTIP
Physicochemical Analysis
C85H130N20O22S1
ADCGHSWV
IY
1816.15
9.56
2
1
7
+1
0.99
-0.450
83.57
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
2980
164.08
5
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
1
E
1
Q
0
G
0
H
2
I
1
L
1
K
1
M
1
F
1
P
0
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 1 M: 1 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
14
C85H130N20O22S1
1816.15
9.56
+1
0.99
-0.450
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini and exhibits indirect hemolytic activity against human erythrocytes. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:14769867}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bungarus candidus (Malayan krait)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini and exhibits indirect hemolytic activity against human erythrocytes. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides..
Basic phospholipase A2 T1-2 A chain (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase T1-2 A)
snake
Phospholipase A2 family, Group I subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14769867}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini and exhibits indirect hemolytic activity against human erythrocytes. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:14769867}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bungarus candidus (Malayan krait)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini and exhibits indirect hemolytic activity against human erythrocytes. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides..
Basic phospholipase A2 T1-1 A chain (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase T1-1 A)
snake
Phospholipase A2 family, Group I subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14769867}.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group I subfamily
Basic phospholipase A2 T1-2 A chain (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase T1-2 A) Basic phospholipase A2 T1-1 A chain (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase T1-1 A)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:14769867}.
snake