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Peptide record

TPDB35921

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB35921
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NLLQFRKMIKKMTGKEVVWYAFYGCYCGGGGK
Physicochemical Analysis
C169H259N43O41S4
DHPS
G
3677.42
9.95
6
1
14
+5
-0.35
-0.178
57.81
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
10095
274.51
8
Residue Composition
number
1
A
1
R
1
N
0
D
2
C
1
E
1
Q
6
G
0
H
1
I
2
L
5
K
2
M
2
F
0
P
0
S
1
T
1
W
3
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 2 E: 1 Q: 1 G: 6 H: 0 I: 1 L: 2 K: 5 M: 2 F: 2 P: 0 S: 0 T: 1 W: 1 Y: 3 V: 2
Chemical Descriptors
32
C169H259N43O41S4
3677.42
9.95
+5
-0.35
-0.178
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Basic phospholipase A2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Calcium Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily
Basic phospholipase A2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake