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Peptide record

TPDB35919

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB35919
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NLLQFNKMIKIMTKKNAIPFYSS
Physicochemical Analysis
C126H205N31O32S2
RDCEGHWV
K
2730.32
10.64
4
0
11
+4
0.77
-0.109
89.13
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
1490
54.57
8
Residue Composition
number
1
A
0
R
3
N
0
D
0
C
0
E
1
Q
0
G
0
H
3
I
2
L
4
K
2
M
2
F
1
P
2
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 3 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 3 L: 2 K: 4 M: 2 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C126H205N31O32S2
2730.32
10.64
+4
0.77
-0.109
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that displays presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:15032748}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Protobothrops mangshanensis (Mangshan pitviper) (Zhaoermia mangshanensis)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that displays presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides..
Basic phospholipase A2 mangshantoxin (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that displays edema-inducing activities, as well as presynaptic neurotoxicity and myotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity). {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Protobothrops tokarensis (Tokara habu) (Trimeresurus tokarensis)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that displays edema-inducing activities, as well as presynaptic neurotoxicity and myotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity)..
Basic phospholipase A2 Pto-N6 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Myotoxin Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15032748}.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin Myotoxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily
Basic phospholipase A2 mangshantoxin (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Basic phospholipase A2 Pto-N6 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland. TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15032748}.
snake