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Peptide record

TPDB35910

Neurotoxin Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB35910
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NLAQFGFMIRCANGGSRSALDYADYGC
Physicochemical Analysis
C124H186N36O39S3
EHKPTWV
AG
2901.24
6.09
2
2
12
-0
-1.16
-0.019
58.15
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
3105
107.02
9
Residue Composition
number
4
A
2
R
2
N
2
D
2
C
0
E
1
Q
4
G
0
H
1
I
2
L
0
K
1
M
2
F
0
P
2
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 2 D: 2 C: 2 E: 0 Q: 1 G: 4 H: 0 I: 1 L: 2 K: 0 M: 1 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
27
C124H186N36O39S3
2901.24
6.09
-0
-1.16
-0.019
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Heterotrimer: blocks the voltage-dependent L-type calcium channels from the heart, and the small conductance calcium-activated potassium channels in the chromaffin cells and in the brain. In vivo, shows high toxicity to mice. {ECO:0000269|PubMed:9242659}. FUNCTION: Monomer: Snake venom phospholipase A2 (PLA2) that has neurotoxic activities. Voltage-dependently affects ionic currents in chick (Gallus domesticus) dorsal root ganglion cells (PubMed:1373076). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:1373076). {ECO:0000269|PubMed:1373076}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Heterotrimer: blocks the voltage-dependent L-type calcium channels from the heart, and the small conductance calcium-activated potassium channels in the chromaffin cells and in the brain. In vivo, shows high toxicity to mice.. FUNCTION: Monomer: Snake venom phospholipase A2 (PLA2) that has neurotoxic activities.
Phospholipase A2 taicatoxin (TCX) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group I subfamily
Evidence at protein level
Calcium Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Hydrolase Ion channel impairing toxin Lipid degradation Lipid metabolism Metal-binding Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:1373076, ECO:0000269|PubMed:1485334}.
Additional Detail Fields 7 fields
Calcium Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Hydrolase Ion channel impairing toxin Lipid degradation Lipid metabolism Metal-binding Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Phospholipase A2 family, Group I subfamily
Phospholipase A2 taicatoxin (TCX) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:1373076, ECO:0000269|PubMed:1485334}.
snake