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Peptide record

TPDB35782

Neurotoxin Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB35782
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
NCPAGCRSQGCCM
Physicochemical Analysis
C47H80N18O17S5
DEHILKFTWYV
C
1329.56
7.84
1
0
2
+1
1.05
-0.077
7.69
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
250
18.80
7
Residue Composition
number
1
A
1
R
1
N
0
D
4
C
0
E
1
Q
2
G
0
H
0
I
0
L
0
K
1
M
0
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C47H80N18O17S5
1329.56
7.84
+1
1.05
-0.077
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). Reversibly blocks calcium current in the dorsal-root ganglion neurons of the rat (high voltage-activated channels but not low voltage-activated channels). Does not modify the voltage dependency of activation and inactivation. {ECO:0000269|PubMed:20920515}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). Reversibly blocks calcium current in the dorsal-root ganglion neurons of the rat (high voltage-activated channels but not low voltage-activated channels).
Omega-conotoxin Cl16a (Conotoxin CalTx) (Omega-conotoxin Cl15a)
cone snail
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20363338}.
Additional Detail Fields 6 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Omega-conotoxin Cl16a (Conotoxin CalTx) (Omega-conotoxin Cl15a)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20363338}.
cone snail