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Peptide record

TPDB35775

Neurotoxin Toxicity modified_plain modified
43 amino acids
Basic Information
3D PDB MODEL
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TPDB35775
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 43-aa modified multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
NCIDFGGDCDGEKDDCQCCXRNGYCSCYNLFGYLKRGCKXEVG
Physicochemical Analysis
C186H280N54O64S8
AHMPTW
C
4553.07
4.39
5
7
9
-2
8.46
-0.577
33.95
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
4970
109.16
16
Residue Composition
number
0
A
2
R
3
N
5
D
8
C
2
E
1
Q
7
G
0
H
1
I
2
L
3
K
0
M
2
F
0
P
1
S
0
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 3 D: 5 C: 8 E: 2 Q: 1 G: 7 H: 0 I: 1 L: 2 K: 3 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 3 V: 1
Chemical Descriptors
43
C186H280N54O64S8
4553.07
4.39
-2
8.46
-0.577
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav)..
Omega-agatoxin-Aa3c (Omega-AGTX-Aa3c) (Omega-agatoxin IIIC) (Omega-Aga-IIIC) (Omega-agatoxin-3C)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Omega-agatoxin-Aa3c (Omega-AGTX-Aa3c) (Omega-agatoxin IIIC) (Omega-Aga-IIIC) (Omega-agatoxin-3C)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider