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Peptide record

TPDB35769

Neurotoxin Toxicity standard
82 amino acids
Basic Information
3D PDB MODEL
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TPDB35769
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 82-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MWLKIQVFLLAITLITLGIQAEPNSSPNNPLIEEEARACAGLYKKCGKGASPCCEDRPCKCDLAMGNCICKKKFIEFFGGGK
Physicochemical Analysis
C394H636N104O111S10
H
K
8926.61
8.09
11
8
31
+3
13.49
0.041
83.41
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
83.91
20
Residue Composition
number
7
A
2
R
4
N
2
D
8
C
6
E
2
Q
8
G
0
H
7
I
8
L
9
K
2
M
4
F
5
P
3
S
2
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 7 R: 2 N: 4 D: 2 C: 8 E: 6 Q: 2 G: 8 H: 0 I: 7 L: 8 K: 9 M: 2 F: 4 P: 5 S: 3 T: 2 W: 1 Y: 1 V: 1
Chemical Descriptors
82
C394H636N104O111S10
8926.61
8.09
+3
13.49
0.041
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1). Induces immediate clockwise gyration and flaccid paralysis after 6 hours at dose levels of 5 ug per mouse.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Antagonist of L-type calcium channels (Cav1/CACNA1). Induces immediate clockwise gyration and flaccid paralysis after 6 hours at dose levels of 5 ug per mouse.
Omega-ctenitoxin-Pn1a (Omega-CNTX-Pn1a) (Neurotoxin Tx3-2) (PNTx3-2)
spider
Neurotoxin 02 (plectoxin) family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8446961}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family
Omega-ctenitoxin-Pn1a (Omega-CNTX-Pn1a) (Neurotoxin Tx3-2) (PNTx3-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8446961}.
spider