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Peptide record

TPDB35736

Neurotoxin Toxicity standard
87 amino acids
Basic Information
3D PDB MODEL
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TPDB35736
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 87-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MVNMKASMFLTFAGLVLLFVVCYASESEEKEFPKEMLSSIFAVDNDFKQEERDCAGYMRECKEKLCCSGYVCSSRWKWCVLPAPWRR
Physicochemical Analysis
C452H693N115O127S12
H
E
10154.89
6.37
12
12
38
-0
14.09
-0.079
66.09
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
21345
210.19
22
Residue Composition
number
6
A
5
R
2
N
3
D
7
C
9
E
1
Q
3
G
0
H
1
I
7
L
7
K
5
M
6
F
3
P
8
S
1
T
3
W
3
Y
7
V
Amino Acid Distribution
A: 6 R: 5 N: 2 D: 3 C: 7 E: 9 Q: 1 G: 3 H: 0 I: 1 L: 7 K: 7 M: 5 F: 6 P: 3 S: 8 T: 1 W: 3 Y: 3 V: 7
Chemical Descriptors
87
C452H693N115O127S12
10154.89
6.37
-0
14.09
-0.079
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: [Mu-theraphotoxin-Hs1a]: Probable sodium channel pore blocker that dose-dependently inhibits voltage-gated sodium channels (VGSC) on DUM neurons in a way similar to tetrodotoxin (PubMed:20506577). Has no effect on the kinetics of activation and inactivation (PubMed:20506577). Does not seem to interact with VGSC in an inactivated state (PubMed:20506577). In vivo, reversibly paralyzes cockroaches, and can enhance the muscular contraction elicited by stimulating its nerve (PubMed:14614533). {ECO:0000269|PubMed:14614533, ECO:0000269|PubMed:20506577}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
[Mu-theraphotoxin-Hs1a]: Probable sodium channel pore blocker that dose-dependently inhibits voltage-gated sodium channels (VGSC) on DUM neurons in a way similar to tetrodotoxin (PubMed:20506577). Has no effect on the kinetics of activation and inactivation (PubMed:20506577).
Mu-theraphotoxin-Hs1a (Mu-TRTX-Hs1a) (Huwentoxin-3) (Huwentoxin-III) (HwTx-III) [Cleaved into: U2-theraphotoxin-Hs1b (U2-TRTX-Hs1b) (HWTX-IIIa) (Mutant of huwentoxin-3) (Mutant of huwentoxin-III) (mHWTX-III)]
spider
Neurotoxin 10 (Hwtx-1) family, 51 (Hntx-8) subfamily, Hntx-8 sub-subfamily
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 51 (Hntx-8) subfamily, Hntx-8 sub-subfamily
Mu-theraphotoxin-Hs1a (Mu-TRTX-Hs1a) (Huwentoxin-3) (Huwentoxin-III) (HwTx-III) [Cleaved into: U2-theraphotoxin-Hs1b (U2-TRTX-Hs1b) (HWTX-IIIa) (Mutant of huwentoxin-3) (Mutant of huwentoxin-III) (mHWTX-III)]
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider