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Peptide record

TPDB35656

Neurotoxin Toxicity standard
86 amino acids
Basic Information
3D PDB MODEL
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TPDB35656
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 86-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MTFKLFVVVTLVLAIYVATAEEAMKDDSEPAERGCIKYGDRCGSPHGLPSNCCNDWKYKGRCGCTMGVCTCGPNCPSRGCDWSKKG
Physicochemical Analysis
C397H624N112O121S13
Q
CG
9318.78
7.72
12
9
27
+2
15.16
-0.244
53.26
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16095
172.72
26
Residue Composition
number
5
A
4
R
3
N
5
D
10
C
4
E
0
Q
10
G
1
H
2
I
4
L
7
K
3
M
2
F
5
P
5
S
5
T
2
W
3
Y
6
V
Amino Acid Distribution
A: 5 R: 4 N: 3 D: 5 C: 10 E: 4 Q: 0 G: 10 H: 1 I: 2 L: 4 K: 7 M: 3 F: 2 P: 5 S: 5 T: 5 W: 2 Y: 3 V: 6
Chemical Descriptors
86
C397H624N112O121S13
9318.78
7.72
+2
15.16
-0.244
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin active against S.frugiperda larvae. May act on sodium channels (Nav).

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Loxosceles intermedia (Brown spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Toxin active against S.frugiperda larvae. May act on sodium channels (Nav).
U2-sicaritoxin-Li1a (U2-SCRTX-Li1a) (LiTx3) (Toxin 3)
spider
Neurotoxin 39 family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 39 family
U2-sicaritoxin-Li1a (U2-SCRTX-Li1a) (LiTx3) (Toxin 3)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider