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Peptide record

TPDB35356

Neurotoxin Toxicity standard
81 amino acids
Basic Information
3D PDB MODEL
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TPDB35356
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 81-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MRASMFLALAGLVLLFVVCYASESEEKEFPRELLFKFFAVDDFKGEERACKGVFDACTPGKNECCPNRVCSDKHKWCKWKL
Physicochemical Analysis
C420H644N108O114S9
QI
K
9318.93
7.56
14
12
34
+1
16.01
-0.084
68.64
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12865
138.05
15
Residue Composition
number
7
A
4
R
2
N
4
D
7
C
8
E
0
Q
4
G
1
H
0
I
8
L
9
K
2
M
8
F
3
P
4
S
1
T
2
W
1
Y
6
V
Amino Acid Distribution
A: 7 R: 4 N: 2 D: 4 C: 7 E: 8 Q: 0 G: 4 H: 1 I: 0 L: 8 K: 9 M: 2 F: 8 P: 3 S: 4 T: 1 W: 2 Y: 1 V: 6
Chemical Descriptors
81
C420H644N108O114S9
9318.93
7.56
+1
16.01
-0.084
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Lethal toxin with multiple biological activities. Inhibits voltage-gated TTX-sensitive sodium channels in DRG neurons (IC(50)=55 nM) and also shows activity when directly tested on Nav1.7/SCN9A (IC(50)=25.1-630 nM) (PubMed:17451655, PubMed:21731778, PubMed:31234412). Inhibits N-type calcium channels (Cav2.2/CACNA1B (IC(50)=100 nM)) (PubMed:11024489, PubMed:17451655). Also blocks neuromuscular transmission (PubMed:10736477, PubMed:8212049, PubMed:9028007). In vivo, intrathecal injected toxin shows analgesic activity in the rat formalin-induced pain model, without induction of motor dysfunction in rats. {ECO:0000269|PubMed:15581678}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Lethal toxin with multiple biological activities. Inhibits voltage-gated TTX-sensitive sodium channels in DRG neurons (IC(50)=55 nM) and also shows activity when directly tested on Nav1.7/SCN9A (IC(50)=25.1-630 nM) (PubMed:17451655, PubMed:21731778, PubMed:31234412).
Mu/omega-theraphotoxin-Hs1a (Mu/omega-TRTX-Hs1a) (Huwentoxin-1) (HwTx-1) (Huwentoxin-I) (HwTx-I)
spider
Neurotoxin 10 (Hwtx-1) family, 23 (HwTx-I) subfamily
Evidence at protein level
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8136023, ECO:0000305|Ref.3}.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 23 (HwTx-I) subfamily
Mu/omega-theraphotoxin-Hs1a (Mu/omega-TRTX-Hs1a) (Huwentoxin-1) (HwTx-1) (Huwentoxin-I) (HwTx-I)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:8136023, ECO:0000305|Ref.3}.
spider