TPDB

3D PDB MODEL

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TPDB ID TPDB35344

Activity

Neurotoxin Toxicity

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 82-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.

Sequence

MRTIVFLIVSILLLSSAVLMLAEGNAASHELQEYPIEESLEEQRKCVDGSCDPYSSDAPRCCGSQICQCIFFVPCYCKYRGK

FASTA

>TPDB35344|Neurotoxin;Toxicity|length=82
MRTIVFLIVSILLLSSAVLMLAEGNAASHELQEYPIEESLEEQRKCVDGSCDPYSSDAPRCCGSQICQCIFFVPCYCKYRGK

Formula C399H632N104O122S10

Absent Amino Acids W

Common Amino Acids S

Mass 9158.63

PI 4.74

Basic Residues 8

Acidic Residues 10

Hydrophobic Residues 33

Net Charge -3

Boman Index 14.52

Hydrophobicity 0.160

Aliphatic Index 90.37

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6460

Absorbance 280nm 70.53

Polar Residues 27

number

5

A

4

R

1

N

3

D

8

C

7

E

4

Q

4

G

1

H

6

I

8

L

3

K

2

M

3

F

4

P

9

S

1

T

0

W

4

Y

5

V

Amino Acid Distribution

A: 5 R: 4 N: 1 D: 3 C: 8 E: 7 Q: 4 G: 4 H: 1 I: 6 L: 8 K: 3 M: 2 F: 3 P: 4 S: 9 T: 1 W: 0 Y: 4 V: 5

Length

82

Formula

C399H632N104O122S10

Mass

9158.63

PI

4.74

Net Charge

-3

Boman Index

14.52

Hydrophobicity

0.160

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Induces flaccid paralysis when injected into lepidopteran larvae. Intracranial injection into mice causes awkwardness of movement and laboured respiration until death. {ECO:0000269|PubMed:12860384}.

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Macrothele gigas (Japanese funnel web spider)

Neurotoxin Type Neurotoxin

Mechanism

Induces flaccid paralysis when injected into lepidopteran larvae. Intracranial injection into mice causes awkwardness of movement and laboured respiration until death..

Protein Name U7-hexatoxin-Mg1a (U7-HXTX-Mg1a) (Neurotoxin magi-6)

Venom Taxon Group spider

Protein Family RTX family

Protein Existence Evidence at protein level

Keywords Amidation Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Signal Toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12860384, ECO:0000305}.

Keywords

Amidation Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Signal Toxin

Neurotoxin_Type

Neurotoxin

Protein_Existence

Evidence at protein level

Protein_Family

RTX family

Protein_Name

U7-hexatoxin-Mg1a (U7-HXTX-Mg1a) (Neurotoxin magi-6)

Tissue_Specificity

TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:12860384, ECO:0000305}.

Venom_Taxon_Group

spider