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Peptide record

TPDB35341

Neurotoxin Toxicity standard
70 amino acids
Basic Information
3D PDB MODEL
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TPDB35341
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 70-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MRAIISLFLISAMVFSMIQAVPEEEGLQLSEDERGGCLPHNRFCNALSGPRCCSGLKCKELSIWDSRCLG
Physicochemical Analysis
C332H538N94O99S9
TY
L
7719.03
5.60
8
8
27
-1
11.52
0.163
92.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
76.11
18
Residue Composition
number
4
A
5
R
2
N
2
D
6
C
6
E
2
Q
6
G
1
H
5
I
9
L
2
K
3
M
3
F
3
P
8
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 5 N: 2 D: 2 C: 6 E: 6 Q: 2 G: 6 H: 1 I: 5 L: 9 K: 2 M: 3 F: 3 P: 3 S: 8 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
70
C332H538N94O99S9
7719.03
5.60
-1
11.52
0.163
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insect active toxin causing rapid but reversible paralysis in crickets. No activity shown in mammals. Suppresses the excitatory postsynaptic potentials evoked in lobster neuromuscular synaptic preparations, possibly by blocking the presynaptic calcium channel. Induces instantaneous reversible paralysis when injected into crickets. Does not show effect on mammalian Cav2.1/CACNA1A, Cav2.2/CACNA1B and Cav2.3/CACNA1E (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelena orientalis (Funnel-web spider)
Neurotoxin
Insect active toxin causing rapid but reversible paralysis in crickets. No activity shown in mammals.
U2-agatoxin-Ao1a (U2-AGTX-Ao1a) (Agelenin)
spider
Neurotoxin 01 (U2-agtx) family
Evidence at transcript level
Amidation Disulfide bond Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Disulfide bond Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at transcript level
Neurotoxin 01 (U2-agtx) family
U2-agatoxin-Ao1a (U2-AGTX-Ao1a) (Agelenin)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider