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Peptide record

TPDB35319

Neurotoxin Toxicity standard
101 amino acids
Basic Information
3D PDB MODEL
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TPDB35319
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 101-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MRFLVGAVLVVVLVACATAFESDAETFKSLVVEERKCHGDGSKGCATKPDDWCCKNTPCKCPAWSSTSECRCAMDCSRRCKGKRALLLPVETHRLLFPEQW
Physicochemical Analysis
C484H775N139O141S13
IY
C
11214.11
7.90
17
12
36
+3
21.74
-0.098
69.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
17125
152.71
26
Residue Composition
number
9
A
7
R
1
N
5
D
11
C
7
E
1
Q
5
G
2
H
0
I
9
L
8
K
2
M
4
F
5
P
7
S
6
T
3
W
0
Y
9
V
Amino Acid Distribution
A: 9 R: 7 N: 1 D: 5 C: 11 E: 7 Q: 1 G: 5 H: 2 I: 0 L: 9 K: 8 M: 2 F: 4 P: 5 S: 7 T: 6 W: 3 Y: 0 V: 9
Chemical Descriptors
101
C484H775N139O141S13
11214.11
7.90
+3
21.74
-0.098
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin active against insects (S.frugiperda larvae). May act on sodium (Nav) or calcium channels (Cav).

Target

voltage-gated calcium channel (Cav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Loxosceles intermedia (Brown spider)
Neurotoxin Ion channel impairing toxin
Toxin active against insects (S.frugiperda larvae). May act on sodium (Nav) or calcium channels (Cav).
U1-sicaritoxin-Li1a (U1-SCRTX-Li1a) (LiTx1)
spider
Neurotoxin 28 (Litx) family
Evidence at protein level
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15302533}.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Neurotoxin 28 (Litx) family
U1-sicaritoxin-Li1a (U1-SCRTX-Li1a) (LiTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15302533}.
spider