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Peptide record

TPDB35132

Neurotoxin Toxicity standard
99 amino acids
Basic Information
3D PDB MODEL
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TPDB35132
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 99-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MNTIQVIIFAVVLVLTVTVGQADEDSAETSLLRKLEEAEAAMFGQYLEESKNSREKRCIGESVPCDKDDPRCCREYECLKPTGYGWWYASYYCYRKKSG
Physicochemical Analysis
C497H773N131O156S8
H
E
11335.87
4.79
13
16
38
-3
25.46
-0.444
70.91
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
21805
192.35
30
Residue Composition
number
7
A
6
R
2
N
5
D
6
C
11
E
3
Q
6
G
0
H
4
I
7
L
7
K
2
M
2
F
3
P
7
S
5
T
2
W
7
Y
7
V
Amino Acid Distribution
A: 7 R: 6 N: 2 D: 5 C: 6 E: 11 Q: 3 G: 6 H: 0 I: 4 L: 7 K: 7 M: 2 F: 2 P: 3 S: 7 T: 5 W: 2 Y: 7 V: 7
Chemical Descriptors
99
C497H773N131O156S8
11335.87
4.79
-3
25.46
-0.444
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Has minor, but significant effects on the Para/tipE insect sodium channel. {ECO:0000269|PubMed:18687374}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Brachypelma smithi (Mexican red knee tarantula) (Eurypelma smithi)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Has minor, but significant effects on the Para/tipE insect sodium channel..
Omega-theraphotoxin-Bs2a (Omega-TRTX-Bs2a) (Brachypelma smithi toxin 1) (Bs1)
spider
Neurotoxin 14 (magi-1) family, 08 (Ltx-4) subfamily
Evidence at protein level
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18687374}.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 14 (magi-1) family, 08 (Ltx-4) subfamily
Omega-theraphotoxin-Bs2a (Omega-TRTX-Bs2a) (Brachypelma smithi toxin 1) (Bs1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18687374}.
spider