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Peptide record

TPDB35111

Neurotoxin Toxicity standard
78 amino acids
Basic Information
3D PDB MODEL
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TPDB35111
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 78-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MNTATGFIVLLVLATVIGCISADFQGGFEPYEEEDAERIFRRSTCTPTDQPCPYHESCCSGSCTYKANENGNQVKRCD
Physicochemical Analysis
C365H563N101O123S8
W
CET
8590.57
4.36
7
11
24
-5
19.41
-0.356
56.28
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
56.40
29
Residue Composition
number
5
A
4
R
4
N
4
D
7
C
7
E
3
Q
6
G
1
H
4
I
3
L
2
K
1
M
4
F
4
P
5
S
7
T
0
W
3
Y
4
V
Amino Acid Distribution
A: 5 R: 4 N: 4 D: 4 C: 7 E: 7 Q: 3 G: 6 H: 1 I: 4 L: 3 K: 2 M: 1 F: 4 P: 4 S: 5 T: 7 W: 0 Y: 3 V: 4
Chemical Descriptors
78
C365H563N101O123S8
8590.57
4.36
-5
19.41
-0.356
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits insect, but not mammalian, voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P56207}.

Target

voltage-gated calcium channel (Cav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits insect, but not mammalian, voltage-gated calcium channels (Cav)..
Omega-hexatoxin-Hi1a (Omega-HXTX-Hi1a) (Omega-atracotoxin-Hi1a) (AcTx-Hi1) (Omega-AcTx-Hi1a) (SF9 peptide)
spider
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Evidence at protein level
Calcium channel impairing toxin Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368, ECO:0000305|Ref.4}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Omega-hexatoxin-Hi1a (Omega-HXTX-Hi1a) (Omega-atracotoxin-Hi1a) (AcTx-Hi1) (Omega-AcTx-Hi1a) (SF9 peptide)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368, ECO:0000305|Ref.4}.
spider