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Peptide record

TPDB35110

Neurotoxin Toxicity standard
79 amino acids
Basic Information
3D PDB MODEL
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TPDB35110
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 79-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MNTATGFIVLLVLATVIGCISADFQGGFEPYEEEDAERIFRRSPTCIPTGQPCPYNENCCSQSCTYKANENGNQVKRCD
Physicochemical Analysis
C372H577N103O123S8
HW
CE
8716.77
4.32
6
10
25
-4
18.51
-0.344
60.51
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
55.58
30
Residue Composition
number
5
A
4
R
6
N
3
D
7
C
7
E
4
Q
6
G
0
H
5
I
3
L
2
K
1
M
4
F
5
P
4
S
6
T
0
W
3
Y
4
V
Amino Acid Distribution
A: 5 R: 4 N: 6 D: 3 C: 7 E: 7 Q: 4 G: 6 H: 0 I: 5 L: 3 K: 2 M: 1 F: 4 P: 5 S: 4 T: 6 W: 0 Y: 3 V: 4
Chemical Descriptors
79
C372H577N103O123S8
8716.77
4.32
-4
18.51
-0.344
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits insect, but not mammalian, voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P56207}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits insect, but not mammalian, voltage-gated calcium channels (Cav)..
Omega-hexatoxin-Hi1b (Omega-HXTX-Hi1b) (Omega-atracotoxin-Hi1b) (AcTx-Hi1) (Omega-AcTx-Hi1b)
spider
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368, ECO:0000305|Ref.4}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Omega-hexatoxin-Hi1b (Omega-HXTX-Hi1b) (Omega-atracotoxin-Hi1b) (AcTx-Hi1) (Omega-AcTx-Hi1b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368, ECO:0000305|Ref.4}.
spider