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Peptide record

TPDB35103

Neurotoxin Toxicity standard
85 amino acids
Basic Information
3D PDB MODEL
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TPDB35103
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 85-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MNTATGFIVLLVLATVLGAIEAEDAVPDFEGGFASHAREDTVGGKIRRSSVCIPSGQPCPYNEHCCSGSCTYKENENGNTVQRCD
Physicochemical Analysis
C381H600N110O129S7
W
G
9010.03
4.54
8
11
28
-5
21.85
-0.192
68.82
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
37.24
27
Residue Composition
number
7
A
4
R
5
N
4
D
6
C
7
E
2
Q
9
G
2
H
4
I
4
L
2
K
1
M
3
F
4
P
6
S
6
T
0
W
2
Y
7
V
Amino Acid Distribution
A: 7 R: 4 N: 5 D: 4 C: 6 E: 7 Q: 2 G: 9 H: 2 I: 4 L: 4 K: 2 M: 1 F: 3 P: 4 S: 6 T: 6 W: 0 Y: 2 V: 7
Chemical Descriptors
85
C381H600N110O129S7
9010.03
4.54
-5
21.85
-0.192
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal toxin that reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels (Cav) in cockroach DUM neurons. Also causes a modest block of insect sodium channel currents (Nav). Induces potent excitatory symptoms, followed by flaccid paralysis leading to death in house crickets. {ECO:0000269|PubMed:17610847}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Atrax robustus (Sydney funnel-web spider)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal toxin that reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels (Cav) in cockroach DUM neurons. Also causes a modest block of insect sodium channel currents (Nav).
Omega-hexatoxin-Ar1a (Omega-HXTX-Ar1a) (Omega-atracotoxin-Ar1a) (Omega-AcTx-Ar1a)
spider
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Evidence at protein level
Calcium channel impairing toxin Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:17610847, ECO:0000305}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily
Omega-hexatoxin-Ar1a (Omega-HXTX-Ar1a) (Omega-atracotoxin-Ar1a) (Omega-AcTx-Ar1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:17610847, ECO:0000305}.
spider