Back to search

Peptide record

TPDB35084

Neurotoxin Toxicity standard
65 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB35084
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 65-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MNMKILVLVAVLCLVVSTHAERHSKTDMEDSPMIQERKCLPPGKPCYGATQKIPCCGVCSHNNCT
Physicochemical Analysis
C301H501N87O90S11
FW
C
7131.48
7.93
10
5
22
+2
16.39
-0.022
79.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
26.15
21
Residue Composition
number
3
A
2
R
3
N
2
D
7
C
3
E
2
Q
3
G
3
H
3
I
5
L
5
K
4
M
0
F
5
P
4
S
4
T
0
W
1
Y
6
V
Amino Acid Distribution
A: 3 R: 2 N: 3 D: 2 C: 7 E: 3 Q: 2 G: 3 H: 3 I: 3 L: 5 K: 5 M: 4 F: 0 P: 5 S: 4 T: 4 W: 0 Y: 1 V: 6
Chemical Descriptors
65
C301H501N87O90S11
7131.48
7.93
+2
16.39
-0.022
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks N-type calcium channels (Cav2.2/CACNA1B) in rat dorsal root ganglion cells. Elicits no toxic symptoms in either vertebrates or invertebrates during a period of 48 hours post-injection, when it was assayed in vivo by direct injection into mice and cockroaches (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Reversibly blocks N-type calcium channels (Cav2.2/CACNA1B) in rat dorsal root ganglion cells. Elicits no toxic symptoms in either vertebrates or invertebrates during a period of 48 hours post-injection, when it was assayed in vivo by direct injection into mice and cockroaches (By similarity)..
Hainantoxin-X (HNTX-X)
spider
Neurotoxin 36 family, 02 subfamily
Evidence at transcript level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at transcript level
Neurotoxin 36 family, 02 subfamily
Hainantoxin-X (HNTX-X)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider