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Peptide record

TPDB35082

Neurotoxin Toxicity standard
68 amino acids
Basic Information
3D PDB MODEL
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TPDB35082
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 68-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MNMKILVLVAVLCLVVSTHAERHSKTDMEDMEDSPMIQERKCLPPGKPCYGATQKIPCCGVCSHNKCT
Physicochemical Analysis
C317H528N90O96S12
FW
C
7520.95
7.58
11
7
23
+1
19.98
-0.101
75.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
24.80
20
Residue Composition
number
3
A
2
R
2
N
3
D
7
C
4
E
2
Q
3
G
3
H
3
I
5
L
6
K
5
M
0
F
5
P
4
S
4
T
0
W
1
Y
6
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 3 C: 7 E: 4 Q: 2 G: 3 H: 3 I: 3 L: 5 K: 6 M: 5 F: 0 P: 5 S: 4 T: 4 W: 0 Y: 1 V: 6
Chemical Descriptors
68
C317H528N90O96S12
7520.95
7.58
+1
19.98
-0.101
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks N-type calcium channels (Cav2.2/CACNA1B) in rat dorsal root ganglion cells (IC(50)=40 nM). Elicits no toxic symptoms in either vertebrates or invertebrates during a period of 48 hours post-injection, when it was assayed in vivo by direct injection into mice and cockroaches. {ECO:0000269|PubMed:16439354}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Reversibly blocks N-type calcium channels (Cav2.2/CACNA1B) in rat dorsal root ganglion cells (IC(50)=40 nM). Elicits no toxic symptoms in either vertebrates or invertebrates during a period of 48 hours post-injection, when it was assayed in vivo by direct injection into mice and cockroaches..
Omega-theraphotoxin-Hs1a (Omega-TRTX-Hs1a) (Huwentoxin-10) (Huwentoxin-X) (HwTx-X)
spider
Neurotoxin 36 family, 02 subfamily
Evidence at protein level
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16439354}.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 36 family, 02 subfamily
Omega-theraphotoxin-Hs1a (Omega-TRTX-Hs1a) (Huwentoxin-10) (Huwentoxin-X) (HwTx-X)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16439354}.
spider