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Peptide record

TPDB35056

Neurotoxin Toxicity standard
112 amino acids
Basic Information
3D PDB MODEL
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TPDB35056
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 112-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MMKFVVFLACLFVAAHSFAVEGEEEYFEAEVPELERAKALPPGSVCDGNESDCKCYGKWHKCRCPWKWHFTGEGPCTCEKGMKHTCITKLHCPNKAEWGLDWRSEESERSPC
Physicochemical Analysis
C565H843N151O163S14
Q
E
12807.66
5.66
19
18
37
-4
31.49
-0.493
47.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
31105
242.86
25
Residue Composition
number
8
A
4
R
2
N
3
D
11
C
15
E
0
Q
8
G
5
H
1
I
6
L
10
K
3
M
6
F
7
P
6
S
4
T
5
W
2
Y
6
V
Amino Acid Distribution
A: 8 R: 4 N: 2 D: 3 C: 11 E: 15 Q: 0 G: 8 H: 5 I: 1 L: 6 K: 10 M: 3 F: 6 P: 7 S: 6 T: 4 W: 5 Y: 2 V: 6
Chemical Descriptors
112
C565H843N151O163S14
12807.66
5.66
-4
31.49
-0.493
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. This toxin is a blocker of L-type calcium channels (Cav/CACNA1). {ECO:0000269|PubMed:1685511}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically.
Omega-agatoxin-1A (Omega-agatoxin IA) (Omega-Aga-IA) [Cleaved into: Omega-agatoxin-1A major chain Omega-agatoxin-1A minor chain]
spider
Neurotoxin 04 (omega-agtx) family, 01 (type I omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1383207, ECO:0000305|PubMed:2295621}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 01 (type I omega-agtx) subfamily
Omega-agatoxin-1A (Omega-agatoxin IA) (Omega-Aga-IA) [Cleaved into: Omega-agatoxin-1A major chain Omega-agatoxin-1A minor chain]
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1383207, ECO:0000305|PubMed:2295621}.
spider