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Peptide record

TPDB35032

Neurotoxin Toxicity standard
121 amino acids
Basic Information
3D PDB MODEL
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TPDB35032
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 121-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MMTLSPFLLLLIAAVVIGNASEGEVKNEFEERLKDEFKDPSRSEVAEVILLRELEVLEETLFGKEMTSDTEENRNSREKRCMGYDIECNENLPCCKHRKLECVETSGYWWYKRKYCRPIKG
Physicochemical Analysis
C620H988N168O192S10
Q
E
14188.28
4.89
20
24
43
-5
46.10
-0.581
78.10
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
17335
122.18
28
Residue Composition
number
4
A
9
R
6
N
4
D
6
C
20
E
0
Q
6
G
1
H
5
I
13
L
10
K
4
M
4
F
4
P
7
S
5
T
2
W
4
Y
7
V
Amino Acid Distribution
A: 4 R: 9 N: 6 D: 4 C: 6 E: 20 Q: 0 G: 6 H: 1 I: 5 L: 13 K: 10 M: 4 F: 4 P: 4 S: 7 T: 5 W: 2 Y: 4 V: 7
Chemical Descriptors
121
C620H988N168O192S10
14188.28
4.89
-5
46.10
-0.581
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin. Shows competition for site 3 of insect voltage-gated sodium channels (Nav). Induces flaccid paralysis when injected into lepidopteran larvae. Is not toxic to mice when injected intracranially at 20 pmol/g. {ECO:0000269|PubMed:12860384}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin. Shows competition for site 3 of insect voltage-gated sodium channels (Nav).
Mu-hexatoxin-Mg1a (Mu-HXTX-Mg1a) (Neurotoxin magi-2)
spider
Neurotoxin 14 (magi-1) family, 09 (magi-1) subfamily
Evidence at protein level
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12860384}.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 14 (magi-1) family, 09 (magi-1) subfamily
Mu-hexatoxin-Mg1a (Mu-HXTX-Mg1a) (Neurotoxin magi-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12860384}.
spider