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Peptide record

TPDB34741

Neurotoxin Toxicity standard
84 amino acids
Basic Information
3D PDB MODEL
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TPDB34741
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 84-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKVTLIAILTCAAVLVLHTTAAEELEESQLMEVGMPDTELAAVDEERLFECSFSCEIEKEGDKPCKKKKCKGGWKCKFNMCVKV
Physicochemical Analysis
C407H669N103O125S11
Y
E
9358.06
4.98
13
15
33
-3
29.67
-0.027
83.57
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
62.78
17
Residue Composition
number
7
A
1
R
1
N
3
D
7
C
12
E
1
Q
4
G
1
H
3
I
8
L
11
K
4
M
3
F
2
P
3
S
5
T
1
W
0
Y
7
V
Amino Acid Distribution
A: 7 R: 1 N: 1 D: 3 C: 7 E: 12 Q: 1 G: 4 H: 1 I: 3 L: 8 K: 11 M: 4 F: 3 P: 2 S: 3 T: 5 W: 1 Y: 0 V: 7
Chemical Descriptors
84
C407H669N103O125S11
9358.06
4.98
-3
29.67
-0.027
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks neuromuscular transmission. Acts cooperatively to potentiate the activity of huwentoxin-I. Paralyzes locusts and kills mice following intracerebroventricular injection.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Neurotoxin Postsynaptic neurotoxin
Blocks neuromuscular transmission. Acts cooperatively to potentiate the activity of huwentoxin-I.
U1-theraphotoxin-Hs1a (U1-TRTX-Hs1a) (Huwentoxin-7) (Huwentoxin-VII) (HwTx-VII)
spider
Neurotoxin 12 (Hwtx-2) family, 02 (Hwtx-2) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
Neurotoxin Postsynaptic neurotoxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 02 (Hwtx-2) subfamily
U1-theraphotoxin-Hs1a (U1-TRTX-Hs1a) (Huwentoxin-7) (Huwentoxin-VII) (HwTx-VII)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider