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Peptide record

TPDB34686

Neurotoxin Toxicity standard
89 amino acids
Basic Information
3D PDB MODEL
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TPDB34686
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 89-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
MKVSVLITLAVLGVMFVWTSAAEQEDHGSDRRDSPALLKNLLGEEVFQSEERACRELLGGCSKDSDCCAHLECRKKWPYHCVWDWTIGK
Physicochemical Analysis
C441H691N123O132S8
L
10084.56
5.43
14
14
34
-3
21.03
-0.243
82.13
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
23865
236.65
20
Residue Composition
number
6
A
5
R
1
N
6
D
6
C
8
E
2
Q
6
G
3
H
2
I
10
L
6
K
2
M
2
F
2
P
7
S
3
T
4
W
1
Y
7
V
Amino Acid Distribution
A: 6 R: 5 N: 1 D: 6 C: 6 E: 8 Q: 2 G: 6 H: 3 I: 2 L: 10 K: 6 M: 2 F: 2 P: 2 S: 7 T: 3 W: 4 Y: 1 V: 7
Chemical Descriptors
89
C441H691N123O132S8
10084.56
5.43
-3
21.03
-0.243
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin that inhibits voltage-gated sodium channel Nav by shifting the threshold for channel activation to more positive potentials. This toxin moderately inhibits human Nav1.7/SCN9A (IC(50)=459 nM) and weakly inhibits hNav1.2/SCN2A and hNav1.5/SCN5A (<20% inhibition at 1 uM peptide). Inhibition of Nav1.7 is voltage-dependent, with lower inhibition at more positive test pulses. {ECO:0000269|PubMed:26134258}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phlogius sp. (Tarantula spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that inhibits voltage-gated sodium channel Nav by shifting the threshold for channel activation to more positive potentials. This toxin moderately inhibits human Nav1.7/SCN9A (IC(50)=459 nM) and weakly inhibits hNav1.2/SCN2A and hNav1.5/SCN5A (<20% inhibition at 1 uM peptide).
Mu-theraphotoxin-Phlo1a (Mu-TRTX-Phlo1a)
spider
Neurotoxin 10 (Hwtx-1) family, 39 (Jztx-34) subfamily
Evidence at protein level
Amidation Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26134258}.
Additional Detail Fields 7 fields
Amidation Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 39 (Jztx-34) subfamily
Mu-theraphotoxin-Phlo1a (Mu-TRTX-Phlo1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26134258}.
spider