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Peptide record

TPDB34676

Neurotoxin Toxicity standard
115 amino acids
Basic Information
3D PDB MODEL
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TPDB34676
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 115-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKVIATLYGLLFLTVVLGDITEGNENDLVENFREELSEADIPLLKKLEAIEDALLEKDFLPYEEEDRNARPKRCAKVRNWCAKNEDCCCPMKCIGAWYNQQSSCQSTFMGMFKKC
Physicochemical Analysis
C579H916N152O177S12
H
EL
13223.27
4.61
15
20
45
-5
31.58
-0.328
80.61
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
15970
120.77
29
Residue Composition
number
8
A
5
R
7
N
7
D
8
C
13
E
3
Q
5
G
0
H
5
I
13
L
10
K
4
M
5
F
4
P
4
S
4
T
2
W
3
Y
5
V
Amino Acid Distribution
A: 8 R: 5 N: 7 D: 7 C: 8 E: 13 Q: 3 G: 5 H: 0 I: 5 L: 13 K: 10 M: 4 F: 5 P: 4 S: 4 T: 4 W: 2 Y: 3 V: 5
Chemical Descriptors
115
C579H916N152O177S12
13223.27
4.61
-5
31.58
-0.328
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin that slows inactivation of voltage-gated sodium channels (Nav). In vivo, is lethal to both vertebrates and insects. {ECO:0000250|UniProtKB:P13494}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin that slows inactivation of voltage-gated sodium channels (Nav). In vivo, is lethal to both vertebrates and insects..
Delta-hexatoxin-Hi1a (Delta-HXTX-Hi1a) (SF13 peptide)
spider
Neurotoxin 06 (delta-actx) family
Evidence at protein level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 06 (delta-actx) family
Delta-hexatoxin-Hi1a (Delta-HXTX-Hi1a) (SF13 peptide)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32398368}.
spider