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Peptide record

TPDB34658

Neurotoxin Toxicity standard
94 amino acids
Basic Information
3D PDB MODEL
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TPDB34658
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 94-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
MKVFVVLLCLSLAAVYALEERLDKDADIMLDSPADMERAKDGDVEGPAGCKKYDVECDSGECCQKQYLWYKWRPLDCRCLKSGFFSSKCVCRDV
Physicochemical Analysis
C465H732N122O141S12
NHT
D
10672.38
4.69
14
17
38
-3
21.71
-0.185
77.77
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
17460
163.60
21
Residue Composition
number
7
A
5
R
0
N
11
D
9
C
6
E
2
Q
5
G
0
H
1
I
10
L
9
K
3
M
3
F
3
P
6
S
0
T
2
W
4
Y
8
V
Amino Acid Distribution
A: 7 R: 5 N: 0 D: 11 C: 9 E: 6 Q: 2 G: 5 H: 0 I: 1 L: 10 K: 9 M: 3 F: 3 P: 3 S: 6 T: 0 W: 2 Y: 4 V: 8
Chemical Descriptors
94
C465H732N122O141S12
10672.38
4.69
-3
21.71
-0.185
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal toxin (PubMed:8541888, PubMed:8896202). This toxin promotes opening of insect Nav channels. The toxin binds to the S1-S2 and S3-S4 loops in the domain II voltage-sensor of insect Nav channels (i.e., receptor site 4). The American cockroach P.americana is largely resistant to the effects of this toxin due to an unusual sequence within the domain II S1-S2 loop. In vivo, paralyzes lepidopteran and dipteran larvae. Paralyzed insects ultimately die from secondary effects of starvation and dehydration (PubMed:25014760). {ECO:0000269|PubMed:25014760, ECO:0000269|PubMed:8541888, ECO:0000269|PubMed:8896202}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Diguetia canities (Desert bush spider) (Segestria canities)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal toxin (PubMed:8541888, PubMed:8896202). This toxin promotes opening of insect Nav channels.
Beta-diguetoxin-Dc1a (Beta-DGTX-Dc1a) (Dc1a) (Insecticidal toxin DTX9.2)
spider
Neurotoxin 26 (DTX) family
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 26 (DTX) family
Beta-diguetoxin-Dc1a (Beta-DGTX-Dc1a) (Dc1a) (Insecticidal toxin DTX9.2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider